Continuous and unobtrusive monitoring of vital signs can change the face of chronic disease management, as well as preventative and personalized healthcare. Wearable devices can potentially enable such continuous measurements of vital signs, giving insights into patients’ long term physical and mental well-being and consequently enabling personalized interventions to modify behaviors which will drastically improve their mental or physical health. The biggest challenge with wearable devices is robustness to work in unconstrained, realistic environments. We are developing novel contact and non-contact imaging wearables for bio-behavioral sensing which can be used for numerous applications in the wild, ranging from personalized management of chronic diseases to driver monitoring.